Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.56 |
| ▸ | METAP2 | P50579 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9676306 | 0.90 | REN (0.60) | RENMETAP2CYP1A2CYP2D6SPHK1 | |
| SCHEMBL10722383 | 0.84 | REN (0.44) | RENMETAP2CYP1A2 | |
| Hydrochloric Acid SCHEMBL10727716 | 0.83 | REN (0.43) | RENMETAP2CYP1A2 | |
| SCHEMBL7275933 | 0.81 | REN (0.47) | RENMETAP2 | |
| SCHEMBL7275926 | 0.81 | REN (0.47) | RENMETAP2 | |
| SCHEMBL10520380 | 0.80 | REN (0.43) | RENMETAP2 | |
| SCHEMBL10727830 | 0.80 | METAP1 (0.49) | RENMETAP2CYP1A2 | |
| SCHEMBL7288180 | 0.79 | CYP1A2 (0.42) | RENMETAP2CYP1A2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL7437801 | 0.79 | REN (0.46) | RENMETAP2ALDH1A1KMT2A | |
| SCHEMBL9417322 | 0.79 | REN (0.56) | RENMETAP2CYP1A2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589446-B1 | N-(Hydroxyethyl)butanediamide derivatives as renin inhibitors | BOEHRINGER INGELHEIM CA LTD (CA) | 1997-09-03 | — | — | EP | claimed |