Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.57 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.57 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7289370 | 0.99 | L3MBTL1 (0.57) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL7287792 | 0.90 | TSHR (0.70) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL7287955 | 0.90 | TSHR (0.70) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL7295801 | 0.90 | GRIN2D (0.71) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL7289790 | 0.90 | TSHR (0.70) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL7295806 | 0.90 | GRIN2D (0.71) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7290601 | 0.89 | GRIN2D (0.69) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7287373 | 0.89 | GRIN2D (0.69) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7285102 | 0.89 | GRIN2D (0.69) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL2021951 | 0.84 | TSHR (0.59) | GRIN2DGRIN3BADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |