Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281421 | 0.89 | REN (0.38) | RENLTA4HMMP1MMP2MMP3 | |
| SCHEMBL7278622 | 0.88 | REN (0.38) | RENLTA4HMMP1MMP2MMP3 | |
| SCHEMBL7280966 | 0.88 | REN (0.35) | RENLTA4HMMP1MMP2MMP3 | |
| SCHEMBL7287034 | 0.86 | REN (0.37) | RENLTA4H | |
| SCHEMBL7288053 | 0.85 | REN (0.48) | REN | |
| SCHEMBL7279985 | 0.84 | REN (0.36) | RENLTA4HMMP1MMP2MMP3 | |
| SCHEMBL7278479 | 0.84 | REN (0.36) | RENLTA4HMMP1MMP2MMP3 | |
| SCHEMBL7281027 | 0.84 | REN (0.51) | RENMMP1MMP2MMP3 | |
| SCHEMBL7278750 | 0.84 | CYP2C19 (0.36) | RENMMP1MMP2MMP3 | |
| SCHEMBL7281639 | 0.83 | REN (0.45) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589446-B1 | N-(Hydroxyethyl)butanediamide derivatives as renin inhibitors | BOEHRINGER INGELHEIM CA LTD (CA) | 1997-09-03 | — | — | EP | claimed |
| WO-1994007845-A1 | N-(HYDROXYETHYL)BUTANEDIAMIDE DERIVATIVES AS RENIN INHIBITORS | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1994-04-14 | — | — | WO | claimed |