Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 8/20 | 0.65 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.65 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.65 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.65 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.65 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.65 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7295429 | 0.99 | GRIN2B (0.64) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7290028 | 0.82 | GRIN2B (0.73) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7294297 | 0.81 | GRIN2B (0.72) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7289795 | 0.81 | GAA (0.68) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL499394 | 0.79 | GRIN2D (1.00) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL1994218 | 0.78 | GRIN2D (0.98) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9963240 | 0.77 | GRIN2B (0.54) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8485641 | 0.72 | GRIN2B (0.53) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7287517 | 0.72 | GRIN2B (0.51) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7294333 | 0.72 | TSHR (0.62) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | claimed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | claimed |
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |