Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295960 | 0.81 | GRIN2D (0.65) | MEN1KMT2ADRD3RAB9AGRIN2B | |
| SCHEMBL7288263 | 0.81 | GRIN2B (0.65) | GAAMEN1KMT2AOPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL7295429 | 0.80 | GRIN2B (0.64) | GAAMEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL7332146 | 0.79 | SLC6A4 (0.56) | OPRM1OPRD1OPRK1OPRL1DRD3 | |
| SCHEMBL7332152 | 0.79 | SLC6A4 (0.56) | OPRM1OPRD1OPRK1OPRL1DRD3 | |
| SCHEMBL7331271 | 0.78 | GRIN2B (0.55) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL9131979 | 0.78 | GRIN2B (0.55) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL8486097 | 0.78 | GRIN2B (0.45) | GAAMEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL7289790 | 0.76 | TSHR (0.70) | GAAMEN1KMT2APOLBTSHR | |
| SCHEMBL7287955 | 0.76 | TSHR (0.70) | GAAMEN1KMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |