Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | DRD1 | P21728 | 1/20 | 0.68 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9233315 | 1.00 | HTR1A (0.68) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL8902183 | 1.00 | HTR1A (0.68) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL7290792 | 1.00 | HTR1A (0.68) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL8891627 | 1.00 | HTR1A (0.68) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL8891090 | 0.99 | HTR1A (0.70) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| Exaprolol SCHEMBL614255 | 0.85 | CYP1A2 (0.72) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL13148951 | 0.84 | HTR1A (0.75) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| Exaprolol SCHEMBL612844 | 0.84 | CYP1A2 (0.70) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL30295338 | 0.83 | CYP1A2 (0.73) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL14027346 | 0.83 | POLB (0.63) | HTR1APOLBKMT2AMEN1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345056-B1 | Improvements in and relating to serotonin antagonists | LILLY CO ELI (US) | 1995-02-01 | — | — | EP | claimed |
| US-5013761-A | Selective | ELI LILLY AND COMPANY (US) | 1991-05-07 | — | — | US | claimed |
| EP-0345056-A2 | Improvements in and relating to serotonin antagonists | ELI LILLY AND COMPANY (US) | 1989-12-06 | — | — | EP | claimed |
| US-6169105-B1 | POTENTIATING THE ACTION OF PAROXETINE IN INCREASING THE AVAILABILITY OF SEROTONIN, NOREPINEPHRINE AND DOPAMINE IN THE BRAIN BY ADMINISTERING PAROXETINE TO A PATIENT IN NEED THEREOF IN COMBINATION WITH WAY 100635 | ELI LILLY AND COMPANY | 2001-01-02 | — | — | US | disclosed |
| EP-0759299-B1 | Potentiation of serotonin response | LILLY CO ELI (US) | 2000-04-26 | — | — | EP | disclosed |
| US-5958429-A | TREATING DEPRESSION | ELI LILLY AND COMPANY (US) | 1999-09-28 | — | — | US | disclosed |
| US-5776969-A | MIXTURE OF ANTISEROTONIN AGENT AND SEROTONIN RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 1998-07-07 | — | — | US | disclosed |
| WO-1997031629-A1 | TREATMENT OF SLEEP DISORDERS | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |
| EP-0792649-A1 | Treatment of sleep disorders | ELI LILLY AND COMPANY (US) | 1997-09-03 | — | — | EP | disclosed |
| WO-1997006792-A1 | POTENTIATION OF SEROTONIN RESPONSE | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |
| EP-0759299-A1 | Potentiation of serotonin response | ELI LILLY AND COMPANY (US) | 1997-02-26 | — | — | EP | disclosed |
| EP-0642787-A2 | Cessation of tobacco use | ELI LILLY AND COMPANY (US) | 1995-03-15 | — | — | EP | disclosed |
| EP-0345056-B1 | Improvements in and relating to serotonin antagonists | LILLY CO ELI (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| US-5013761-A | Selective | ELI LILLY AND COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| EP-0345056-A2 | Improvements in and relating to serotonin antagonists | ELI LILLY AND COMPANY (US) | 1989-12-06 | — | — | EP | disclosed |