Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297642 | 0.89 | MAPT (0.73) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1938827 | 0.87 | ALDH1A1 (1.00) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29766970 | 0.87 | ALDH1A1 (1.00) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7289077 | 0.85 | MAPT (0.79) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7298095 | 0.82 | TSHR (0.78) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7290785 | 0.82 | MAPT (0.70) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7290710 | 0.81 | TSHR (0.76) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL22986511 | 0.80 | TSHR (0.70) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7298260 | 0.79 | ALDH1A1 (0.73) | MAPTTSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7300309 | 0.79 | TSHR (0.73) | MAPTTSHRALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | claimed |
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | disclosed |