Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626009 | 0.95 | SIGMAR1 (0.65) | SIGMAR1DRD2HTR1AMEN1KMT2A | |
| SCHEMBL7292781 | 0.87 | SIGMAR1 (0.64) | SIGMAR1HTR1AHTR7PARP1 | |
| SCHEMBL11830521 | 0.85 | SIGMAR1 (0.64) | SIGMAR1DRD2MEN1KMT2AHTR7 | |
| SCHEMBL11835559 | 0.85 | SIGMAR1 (0.50) | SIGMAR1DRD2 | |
| SCHEMBL7297566 | 0.85 | SIGMAR1 (0.63) | SIGMAR1DRD2HTR1APARP1 | |
| Hydrochloric Acid SCHEMBL7299927 | 0.84 | SIGMAR1 (0.61) | SIGMAR1DRD2HTR1APARP1 | |
| SCHEMBL11938943 | 0.84 | SIGMAR1 (0.65) | SIGMAR1DRD2HTR1AHTR7 | |
| SCHEMBL5846298 | 0.83 | SIGMAR1 (0.68) | SIGMAR1DRD2HTR1AHTR7PARP1 | |
| SCHEMBL6635917 | 0.82 | SIGMAR1 (0.61) | SIGMAR1DRD2HTR1AHTR7PARP1 | |
| Hydrochloric Acid SCHEMBL5846785 | 0.82 | SIGMAR1 (0.67) | SIGMAR1DRD2HTR1AHTR7PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436157-B1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-23 | — | — | EP | disclosed |
| US-5296487-A | Dopamine antagonist for nervous system disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| US-5264438-A | Dopamine receptor agonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| EP-0436157-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-10 | — | — | EP | disclosed |