Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 19/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 19/20 | 0.60 |
| ▸ | PDE5A | O76074 | 18/20 | 0.60 |
| ▸ | PDE1A | P54750 | 12/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 12/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 12/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285109 | 0.89 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL155132 | 0.86 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL29623702 | 0.86 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL15085278 | 0.79 | PDE5A (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL2473235 | 0.78 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7287261 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL15085332 | 0.74 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7286974 | 0.74 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7276843 | 0.73 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7285598 | 0.72 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557016-B1 | Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor | TANABE SEIYAKU CO (JP) | 1996-06-19 | — | — | EP | disclosed |
| US-5342941-A | Bronchodilating agents | TANABE SEIYAKU CO., LTD. (JP) | 1994-08-30 | — | — | US | disclosed |
| EP-0557016-A1 | Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor | TANABE SEIYAKU CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |