SCHEMBL7289693

SCHEMBL7289693

CCCCOC(=O)[CH]CCCN

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.57
TSHR P16473 3/20 0.53
HPGD P15428 1/20 0.53
HCAR2 Q8TDS4 3/20 0.50
MAPT P10636 2/20 0.47
RAB9A P51151 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
ALDH1A1 P00352 2/20 0.45
THRB P10828 1/20 0.40
CNR1 P21554 1/20 0.40
APP P05067 1/20 0.38
CYP1A2 P05177 2/20 0.38
ESR1 P03372 1/20 0.38
LMNA P02545 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
PDE4D Q08499 1/20 0.38
HTR2C P28335 1/20 0.38
NAAA Q02083 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL128719 0.88 ATM (0.65) ATMTSHRHPGDHCAR2MAPT
SCHEMBL131584 0.86 ATM (0.63) ATMTSHRHPGDHCAR2MAPT
SCHEMBL4740627 0.85 ATM (0.61) ATMTSHRHPGDHCAR2MAPT
SCHEMBL2485450 0.85 ATM (0.61) ATMTSHRHPGDHCAR2MAPT
SCHEMBL130609 0.84 ATM (0.65) ATMTSHRHPGDHCAR2MAPT
SCHEMBL10773388 0.82 CYP1A2 (0.50) ATMHCAR2MAPTNPSR1ALDH1A1
SCHEMBL3772230 0.82 HCAR2 (0.58) ATMTSHRHPGDHCAR2MAPT
SCHEMBL27996791 0.82 ATM (0.63) ATMTSHRHPGDHCAR2MAPT
SCHEMBL6931235 0.81 HCAR2 (0.59) ATMTSHRHPGDHCAR2NPSR1
SCHEMBL11257102 0.81 HCAR2 (0.59) ATMTSHRHPGDHCAR2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5652247-A VASOPRESSIN ANTAGONIST OTSUKA PHARMACEUTICAL CO., LTD (JP) 1997-07-29 US disclosed
US-5436254-A Vaopressin antagonists OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) 1995-07-25 US disclosed
EP-0602209-A1 OXYTOCIN ANTAGONIST OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-06-22 EP disclosed
EP-0382185-B1 Carbostyril derivatives OTSUKA PHARMA CO LTD (JP) 1994-06-15 EP disclosed
WO-1994001113-A1 OXYTOCIN ANTAGONIST OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1994-01-20 WO disclosed
US-5225402-A Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1993-07-06 US disclosed
EP-0382185-A2 Carbostyril derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1990-08-16 EP disclosed