Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288540 | 0.94 | REN (0.58) | RENCTSD | |
| SCHEMBL7288061 | 0.88 | REN (0.60) | RENCTSD | |
| SCHEMBL7288703 | 0.88 | REN (0.60) | RENCTSD | |
| SCHEMBL7398044 | 0.87 | REN (0.59) | RENCTSD | |
| SCHEMBL7389853 | 0.85 | REN (0.58) | RENCTSDLMNABMP1ALDH1A1 | |
| SCHEMBL7391664 | 0.84 | REN (0.66) | RENCTSD | |
| SCHEMBL7390896 | 0.84 | REN (0.66) | RENCTSD | |
| SCHEMBL7391896 | 0.84 | REN (0.66) | RENCTSD | |
| SCHEMBL7392956 | 0.84 | REN (0.62) | RENCTSD | |
| SCHEMBL7386105 | 0.83 | REN (0.55) | RENCTSDLMNABMP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589446-B1 | N-(Hydroxyethyl)butanediamide derivatives as renin inhibitors | BOEHRINGER INGELHEIM CA LTD (CA) | 1997-09-03 | — | — | EP | disclosed |
| WO-1994007845-A1 | N-(HYDROXYETHYL)BUTANEDIAMIDE DERIVATIVES AS RENIN INHIBITORS | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1994-04-14 | — | — | WO | disclosed |