Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | WNT3A | P56704 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719034 | 0.84 | NR4A2 (0.85) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL30121738 | 0.84 | NR4A2 (0.85) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL8834212 | 0.83 | NR4A2 (0.68) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL9000861 | 0.83 | NR4A2 (0.68) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL11483219 | 0.81 | KMT2A (0.67) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL4476891 | 0.81 | NR4A2 (0.65) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL7043064 | 0.79 | NR4A2 (0.63) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL27945874 | 0.78 | ALDH1A1 (0.87) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL354105 | 0.78 | NR4A2 (1.00) | NR4A2MAPTL3MBTL1LMNATDP1 | |
| SCHEMBL11271325 | 0.77 | NR4A2 (0.55) | NR4A2MAPTL3MBTL1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103927-B1 | CONVERTING ENZYME INHIBITORS | Norwich Eaton Pharmaceuticals, Inc. (US) | 1986-06-04 | — | — | EP | disclosed |
| US-4461896-A | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1984-07-24 | — | — | US | disclosed |
| US-4442038-A | Converting enzyme inhibitors | NORWICH EATON PHARMACEUTICALS, INC. | 1984-04-10 | — | — | US | disclosed |
| EP-0103927-A1 | Converting enzyme inhibitors | Norwich Eaton Pharmaceuticals, Inc. (US) | 1984-03-28 | — | — | EP | disclosed |
| EP-0012845-B1 | TETRAHYDROISOQUINOLINE COMPOUNDS, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Tanabe Seiyaku Co., Ltd. (JP) | 1983-06-22 | — | — | EP | disclosed |
| EP-0012845-A1 | Tetrahydroisoquinoline compounds, process for preparing same and pharmaceutical compositions containing them | Tanabe Seiyaku Co., Ltd. (JP) | 1980-07-09 | — | — | EP | disclosed |