Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10419786 | 0.85 | SMN1; SMN2 (0.57) | HIF1ASMN1; SMN2SLC6A2TAAR1PPARG | |
| SCHEMBL7270620 | 0.83 | KCNN4 (0.46) | HIF1ASMN1; SMN2PPARGPPARACYP3A4 | |
| SCHEMBL7383003 | 0.79 | SMN1; SMN2 (0.47) | HIF1ASMN1; SMN2SLC6A2TAAR1PPARG | |
| SCHEMBL3342965 | 0.77 | SMN1; SMN2 (0.53) | HIF1ASMN1; SMN2SLC6A2TAAR1PPARG | |
| SCHEMBL10825185 | 0.76 | HIF1A (0.48) | HIF1ASMN1; SMN2SLC6A2TAAR1PPARG | |
| SCHEMBL27769764 | 0.76 | SMN1; SMN2 (0.48) | HIF1ASMN1; SMN2SLC6A2TAAR1PPARG | |
| SCHEMBL3875184 | 0.76 | SMN1; SMN2 (0.44) | HIF1ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9472890 | 0.75 | SMN1; SMN2 (0.52) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL19827414 | 0.75 | SLC6A2 (0.50) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL3705342 | 0.74 | HIF1A (0.50) | HIF1ASMN1; SMN2SLC6A2TAAR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |
| EP-0307837-A2 | Renin-inhibiting peptidyl heterocycles | ABBOTT LABORATORIES (US) | 1989-03-22 | — | — | EP | disclosed |