Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.42 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284126 | 0.85 | PDE3B (0.45) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL7284442 | 0.83 | PDE3B (0.43) | KDM4EALDH1A1HPGDPDE3BPDE3A | |
| SCHEMBL7434710 | 0.82 | PDE3B (0.41) | KDM4EALDH1A1HPGDPDE3BPDE3A | |
| SCHEMBL7285813 | 0.79 | CYP1A2 (0.50) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL7284949 | 0.76 | AAK1 (0.40) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL7286715 | 0.76 | KCNA5 (0.41) | KDM4EALDH1A1HPGDPDE3BPDE3A | |
| SCHEMBL7285451 | 0.74 | CYP1A2 (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2SQOR | |
| SCHEMBL7291097 | 0.73 | SMN1; SMN2 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL7291809 | 0.73 | KDM4E (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL7290824 | 0.72 | CYP1A2 (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2SQOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200024-B1 | 3-CYANO-PYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| EP-0200024-A2 | 3-Cyano-pyridines, process for their preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1986-11-05 | — | — | EP | disclosed |