Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294020 | 0.89 | AAK1 (0.41) | AAK1CYP3A4ROCK2NR2C2CLK1 | |
| SCHEMBL7292378 | 0.83 | GLA (0.41) | CYP3A4KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL7285326 | 0.83 | AAK1 (0.41) | AAK1CYP3A4ROCK2NR2C2CLK1 | |
| SCHEMBL7294840 | 0.83 | TDP1 (0.44) | KDM4EALDH1A1MAPTHPGDACACB | |
| SCHEMBL7306378 | 0.82 | AAK1 (0.45) | AAK1CYP3A4ROCK2NR2C2CLK1 | |
| SCHEMBL7284472 | 0.82 | L3MBTL1 (0.51) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7284759 | 0.81 | AAK1 (0.42) | AAK1CYP3A4ROCK2NR2C2CLK1 | |
| SCHEMBL7291149 | 0.81 | AAK1 (0.43) | AAK1CYP3A4ROCK2NR2C2CLK1 | |
| SCHEMBL7284947 | 0.81 | GLA (0.42) | CYP3A4KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL7294242 | 0.78 | AURKA (0.47) | AAK1CYP3A4ROCK2NR2C2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200024-B1 | 3-CYANO-PYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| EP-0200024-A2 | 3-Cyano-pyridines, process for their preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1986-11-05 | — | — | EP | disclosed |