Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750266 | 0.93 | MAPT (0.49) | MAPTALDH1A1POLBSIRT6CYP2C9 | |
| SCHEMBL1750267 | 0.93 | MAPT (0.49) | MAPTALDH1A1POLBSIRT6CYP2C9 | |
| SCHEMBL14167563 | 0.85 | MAPT (0.59) | MAPTALDH1A1POLBSIRT6CYP2C9 | |
| SCHEMBL7299663 | 0.82 | NPY5R (0.46) | MAPTALDH1A1POLBLMNAMEN1 | |
| SCHEMBL594885 | 0.81 | MAPT (0.60) | MAPTALDH1A1POLBSIRT6CYP2C9 | |
| SCHEMBL3440216 | 0.80 | MAPT (0.59) | MAPTALDH1A1POLBSIRT6CYP2C9 | |
| SCHEMBL16580726 | 0.78 | SIRT6 (0.56) | MAPTALDH1A1POLBSIRT6CYP2C9 | |
| SCHEMBL1749521 | 0.78 | MCHR1 (0.54) | MAPTALDH1A1POLBSIRT6CYP2C9 | |
| SCHEMBL1749643 | 0.78 | MAPT (0.53) | MAPTALDH1A1POLBSIRT6CYP2C9 | |
| SCHEMBL1749642 | 0.78 | MAPT (0.53) | MAPTALDH1A1POLBSIRT6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503411-B1 | Substituted N-phenylpiperidines and medicaments thereof | BASF AG (DE) | 1995-11-29 | — | — | EP | disclosed |
| US-5296485-A | Substituted N-phenylpiperidines and drugs therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1994-03-22 | — | — | US | disclosed |
| EP-0503411-A1 | Substituted N-phenylpiperidines and medicaments thereof | BASF Aktiengesellschaft (DE) | 1992-09-16 | — | — | EP | disclosed |