Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7296451 | 0.99 | PARP1 (0.49) | PARP1KDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL7299614 | 0.93 | KDM4E (0.49) | PARP1KDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL7287843 | 0.92 | PARP1 (0.49) | PARP1KDM4ETDP1ALDH1A1MAPT | |
| Sulfuric Acid SCHEMBL7329510 | 0.90 | KDM4E (0.49) | PARP1KDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL7297124 | 0.88 | PARP1 (0.53) | PARP1KDM4ETDP1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7301692 | 0.84 | PARP1 (0.56) | PARP1 | |
| SCHEMBL7292780 | 0.83 | PARP1 (0.55) | PARP1KDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL7298716 | 0.83 | PARP1 (0.58) | PARP1KDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL7297348 | 0.82 | KDM4E (0.49) | PARP1KDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL7300024 | 0.82 | PARP1 (0.58) | PARP1KDM4ETDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436157-B1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-23 | — | — | EP | claimed |
| US-5296487-A | Dopamine antagonist for nervous system disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | claimed |
| US-5264438-A | Dopamine receptor agonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-23 | — | — | US | claimed |
| EP-0436157-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-10 | — | — | EP | claimed |
| JP-5078349-A | — | — | None | — | — | JP | disclosed |
| EP-0436157-B1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-23 | — | — | EP | disclosed |
| US-5296487-A | Dopamine antagonist for nervous system disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| US-5264438-A | Dopamine receptor agonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| WO-1993018769-A2 | A NEW USE OF QUINAZOLINE DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-30 | — | — | WO | disclosed |
| JP-H0578349-A | QUINAZOLINE DERIVATIVE AND ITS PRODUCTION | FUJISAWA PHARMACEUT CO LTD | 1993-03-30 | — | — | JP | disclosed |
| EP-0436157-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-10 | — | — | EP | disclosed |