Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 7/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287843 | 0.98 | PARP1 (0.49) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| SCHEMBL7293124 | 0.90 | PARP1 (0.50) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL7296451 | 0.89 | PARP1 (0.49) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| SCHEMBL7297124 | 0.86 | PARP1 (0.53) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| SCHEMBL7299614 | 0.83 | KDM4E (0.49) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| SCHEMBL7297348 | 0.83 | KDM4E (0.49) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| SCHEMBL7297272 | 0.80 | KDM4E (0.63) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| SCHEMBL7289998 | 0.80 | KDM4E (0.57) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| SCHEMBL7298716 | 0.80 | PARP1 (0.58) | KDM4ETDP1ALDH1A1MAPTHPGD | |
| SCHEMBL7292780 | 0.80 | PARP1 (0.55) | KDM4ETDP1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296487-A | Dopamine antagonist for nervous system disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| WO-1993018769-A2 | A NEW USE OF QUINAZOLINE DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-30 | — | — | WO | disclosed |
| WO-1993012794-A1 | USE OF AN ANIMAZOLINE DERIVATIVE FOR THE TREATMENT OF GLAUCOMA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-08 | — | — | WO | disclosed |