Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27194288 | 0.86 | MAPT (0.61) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL22171340 | 0.81 | SIRT6 (0.59) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL5314836 | 0.81 | MAPT (0.64) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL29103 | 0.80 | MAPT (0.60) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL27355 | 0.80 | MAPT (0.60) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL25189631 | 0.79 | MEN1 (0.60) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL594849 | 0.77 | MAPT (0.66) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL27774 | 0.76 | MAPT (1.00) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL6714560 | 0.76 | MEN1 (0.73) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL13114880 | 0.76 | MAPT (0.65) | MAPTALDH1A1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503411-B1 | Substituted N-phenylpiperidines and medicaments thereof | BASF AG (DE) | 1995-11-29 | — | — | EP | disclosed |
| US-5296485-A | Substituted N-phenylpiperidines and drugs therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1994-03-22 | — | — | US | disclosed |
| EP-0503411-A1 | Substituted N-phenylpiperidines and medicaments thereof | BASF Aktiengesellschaft (DE) | 1992-09-16 | — | — | EP | disclosed |