Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290138 | 0.89 | LMNA (0.54) | LMNAHTTGAATSHRALDH1A1 | |
| SCHEMBL7297776 | 0.78 | LMNA (0.58) | LMNAHTTGAATSHRALDH1A1 | |
| SCHEMBL6468908 | 0.76 | LMNA (0.94) | LMNAHTTGAATSHRALDH1A1 | |
| SCHEMBL7299177 | 0.75 | LMNA (0.65) | LMNAHTTGAATSHRALDH1A1 | |
| SCHEMBL6468314 | 0.74 | LMNA (0.69) | LMNAHTTGAATSHRALDH1A1 | |
| SCHEMBL10720116 | 0.73 | LMNA (0.64) | LMNAHTTGAATSHRALDH1A1 | |
| SCHEMBL15175716 | 0.73 | NR4A2 (0.60) | LMNAHTTGAATSHRALDH1A1 | |
| SCHEMBL10717437 | 0.71 | HTT (0.67) | LMNAHTTGAATSHRALDH1A1 | |
| SCHEMBL4072715 | 0.71 | KDM4E (0.51) | LMNAHTTGAAALDH1A1POLB | |
| SCHEMBL6469625 | 0.71 | LMNA (0.69) | LMNAHTTGAATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | claimed |
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | disclosed |