Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 14/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10334228 | 0.99 | SCNN1A (0.43) | SCNN1AGRM5ALDH1A1KDM4EGLA | |
| SCHEMBL1429125 | 0.95 | SCNN1A (0.44) | SCNN1AGRM5ALDH1A1KDM4EGLA | |
| SCHEMBL10461284 | 0.87 | SCNN1A (0.39) | SCNN1AGRM5ALDH1A1KDM4EGLA | |
| SCHEMBL27834090 | 0.86 | SCNN1A (0.47) | SCNN1AGRM5ALDH1A1KDM4EGLA | |
| SCHEMBL1429031 | 0.85 | SCNN1A (0.50) | SCNN1AGRM5ALDH1A1KDM4EGLA | |
| SCHEMBL10463198 | 0.84 | SCNN1A (0.41) | SCNN1AGRM5ALDH1A1KDM4EGLA | |
| SCHEMBL10333871 | 0.83 | PLAU (0.40) | ALDH1A1KDM4EHSD17B10BLMPLAU | |
| SCHEMBL10462678 | 0.83 | SCNN1A (0.41) | SCNN1AGRM5ALDH1A1KDM4EGLA | |
| SCHEMBL1441745 | 0.80 | SCNN1A (0.48) | SCNN1AGRM5ALDH1A1KDM4EGLA | |
| SCHEMBL10463201 | 0.78 | PLAU (0.46) | SCNN1AGRM5ALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4980352-A | HYPOTENSIVE AGENTS; POTASSIUM-CONSERVING | ICI AMERICAS INC. (US) | 1990-12-25 | — | — | US | disclosed |
| US-4952583-A | DIURETIC HYPOTENSIVE AGENTS | ICI AMERICAS INC. (US) | 1990-08-28 | — | — | US | disclosed |
| US-4910202-A | Hypotensive agent, inducing eukalemic duiresis in mammals | ICI AMERICAS INC. (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0343865-A1 | Bicyclic compounds | ICI AMERICAS INC. (US) | 1989-11-29 | — | — | EP | disclosed |
| EP-0343866-A1 | Aminophenol derivatives | ICI AMERICAS INC. (US) | 1989-11-29 | — | — | EP | disclosed |
| EP-0293170-A1 | Aminomethylphenolic pyrazines, their preparation and use | ICI AMERICAS INC. (US) | 1988-11-30 | — | — | EP | disclosed |