Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298726 | 0.89 | GRM2 (0.55) | GRM2MAOAMAOB | |
| SCHEMBL3181922 | 0.85 | GRM2 (0.60) | GRM2MAOAMAOB | |
| SCHEMBL4163689 | 0.85 | GRM2 (0.60) | GRM2MAOAMAOB | |
| SCHEMBL6955426 | 0.82 | GRM2 (0.65) | GRM2 | |
| SCHEMBL3331808 | 0.82 | GRM2 (0.65) | GRM2 | |
| SCHEMBL8799676 | 0.82 | GRM2 (0.65) | GRM2 | |
| SCHEMBL7292796 | 0.81 | GRM2 (0.47) | GRM2MAOAMAOB | |
| SCHEMBL6601309 | 0.81 | GRM2 (0.49) | GRM2 | |
| SCHEMBL6603720 | 0.81 | GRM2 (0.49) | GRM2 | |
| SCHEMBL11529788 | 0.80 | GRM2 (0.62) | GRM2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459256-B1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GMBH (DE) | 1995-07-12 | — | — | EP | disclosed |
| US-5232931-A | OXAZOLIDINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0300272-B1 | OXAZOLIDINONES | MERCK PATENT GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |
| EP-0459256-A1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GmbH (DE) | 1991-12-04 | — | — | EP | disclosed |
| US-4970217-A | NEUROLEPTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-11-13 | — | — | US | disclosed |
| EP-0300272-A1 | Oxazolidinones | MERCK PATENT GmbH (DE) | 1989-01-25 | — | — | EP | disclosed |