Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.60 |
| ▸ | FADS1 | O60427 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3181922 | 1.00 | GRM2 (0.60) | GRM2FADS1MAOAMAOB | |
| SCHEMBL7116724 | 0.88 | GRM2 (0.45) | GRM2MAOB | |
| SCHEMBL7116727 | 0.88 | GRM2 (0.45) | GRM2MAOB | |
| SCHEMBL8860802 | 0.86 | GRM2 (0.55) | GRM2FADS1MAOAMAOB | |
| SCHEMBL8594767 | 0.86 | GRM2 (0.55) | GRM2FADS1MAOAMAOB | |
| SCHEMBL6967219 | 0.85 | GRM2 (0.57) | GRM2FADS1 | |
| SCHEMBL6957780 | 0.85 | GRM2 (0.57) | GRM2FADS1 | |
| SCHEMBL6960959 | 0.85 | GRM2 (0.57) | GRM2FADS1 | |
| SCHEMBL7293545 | 0.85 | GRM2 (0.62) | GRM2MAOAMAOB | |
| SCHEMBL8799676 | 0.85 | GRM2 (0.65) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660465-B1 | PROCESS FOR THE SYNTHESIS OF BIARYL OXAZOLIDINONES | MELINTA THERAPEUTICS INC (US) | 2014-12-17 | — | — | EP | disclosed |
| EP-1660465-B1 | PROCESS FOR THE SYNTHESIS OF BIARYL OXAZOLIDINONES | MELINTA THERAPEUTICS INC (US) | 2014-12-17 | — | — | EP | disclosed |
| US-8895741-B2 | Process for the synthesis of biaryl oxazolidinones | MELINTA THERAPEUTICS, INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20130066076-A1 | Process for the Synthesis of Biaryl Oxazolidinones | MELINTA SUBSIDIARY CORP. | 2013-03-14 | — | — | US | disclosed |
| US-8324398-B2 | Process for the synthesis of biaryl oxazolidinones | RIB-X PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100022772-A1 | PROCESS FOR THE SYNTHESIS OF BIARYL OXAZOLIDNONES | RIB-X PHARMACEUTICALS, INC. (US) | 2010-01-28 | — | — | US | disclosed |
| US-20090105484-A1 | PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OXAZOLIDINONES AS INTERMEDIATES FOR ANTIBACTERIAL AGENTS | ASTRAZENECA (SE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105484-A1 | PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OXAZOLIDINONES AS INTERMEDIATES FOR ANTIBACTERIAL AGENTS | ASTRAZENECA (SE) | 2009-04-23 | — | — | US | disclosed |
| US-20070270357-A1 | Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. | 2007-11-22 | — | — | US | disclosed |
| US-20070270357-A1 | Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. | 2007-11-22 | — | — | US | disclosed |
| EP-1753751-A1 | PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OXAZOLIDINONES AS INTERMEDIATES FOR ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2007-02-21 | — | — | EP | disclosed |
| US-7129259-B2 | Halogenated biaryl heterocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2006-10-31 | — | — | US | disclosed |
| US-20060148869-A1 | Halogenated biaryl heterocyclic compounds and methods of making and using the same | CHEN SHILI | 2006-07-06 | — | — | US | disclosed |
| WO-2005116017-A1 | PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OXAZOLIDINONES AS INTERMEDIATES FOR ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |
| US-20050153971-A1 | Halogenated biaryl heterocyclic compounds and methods of making and using the same | MELINTA SUBSIDIARY CORP. | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153971-A1 | Halogenated biaryl heterocyclic compounds and methods of making and using the same | PROKR1, PROKR2, PCNA | GRM2 4023/4885FADS1 1524/4885MAOA 1365/4885 |
| US-20130066076-A1 | Process for the Synthesis of Biaryl Oxazolidinones | PCNA, PGC, SBDS | GRM2 3664/4885FADS1 1565/4885MAOA 1272/4885 |
| US-20060148869-A1 | Halogenated biaryl heterocyclic compounds and methods of making and using the same | PCNA, PROKR1, BCOR | GRM2 3957/4885FADS1 1504/4885MAOA 1171/4885 |
| US-20090105484-A1 | PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OXAZOLIDINONES AS INTERMEDIATES FOR ANTIBACTERIAL AGENTS | OXA1L, INTS6, CYP2F1 | GRM2 3703/4885FADS1 3728/4885MAOA 898/4885 |
| US-20100022772-A1 | PROCESS FOR THE SYNTHESIS OF BIARYL OXAZOLIDNONES | PCNA, PGC, MKI67 | GRM2 3325/4885FADS1 1421/4885MAOA 824/4885 |
| US-20070270357-A1 | Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same | PAICS, MAP2K4, GIPR | GRM2 4501/4885FADS1 2364/4885MAOA 1209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.