SCHEMBL7293999

SCHEMBL7293999

Oc1ccc(C2CNCC2c2cccc(O)c2Cl)cc1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.50
QDPR P09417 1/20 0.40
MAPK1 P28482 2/20 0.38
TSHR P16473 2/20 0.38
CYP3A4 P08684 2/20 0.38
NFKB1 P19838 2/20 0.38
THPO P40225 2/20 0.38
HSD17B10 Q99714 2/20 0.38
ALOX15 P16050 1/20 0.38
CHRNB2 P17787 2/20 0.38
CHRNA4 P43681 2/20 0.38
KDM4E B2RXH2 2/20 0.37
MAPT P10636 2/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37
PMP22 Q01453 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
MEN1 O00255 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7293987 1.00 PARP1 (0.50) PARP1QDPRMAPK1TSHRCYP3A4
SCHEMBL7297389 1.00 PARP1 (0.50) PARP1QDPRMAPK1TSHRCYP3A4
Bromide SCHEMBL7294464 0.99 PARP1 (0.49) PARP1QDPRMAPK1TSHRCYP3A4
Hydrochloric Acid SCHEMBL9427161 0.99 PARP1 (0.49) PARP1QDPRMAPK1TSHRCYP3A4
Hydrochloric Acid SCHEMBL9427149 0.99 PARP1 (0.49) PARP1QDPRMAPK1TSHRCYP3A4
Bromide SCHEMBL7294458 0.99 PARP1 (0.49) PARP1QDPRMAPK1TSHRCYP3A4
Bromide SCHEMBL7294448 0.99 PARP1 (0.49) PARP1QDPRMAPK1TSHRCYP3A4
Hydrochloric Acid SCHEMBL9427156 0.99 PARP1 (0.49) PARP1QDPRMAPK1TSHRCYP3A4
SCHEMBL7304620 0.84 PARP1 (0.45) PARP1QDPRMAPK1TSHRCYP3A4
Bromide SCHEMBL7443323 0.83 PARP1 (0.45) PARP1QDPRMAPK1TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0476156-B1 SOLID ORAL PREPARATION CONTAINING CATECHOL COMPOUND EISAI CO LTD (JP) 1996-08-07 EP claimed
US-5444083-A DOPAMINE AGONIST FOR TREATING OR PREVENTION OF HYPERTENSION OR HEART FAILURE EISAI CO., LTD. (JP) 1995-08-22 US claimed
US-5292521-A And an organic acid or salt EISAI CO., LTD. (JP) 1994-03-08 US claimed
EP-0381235-B1 PYRROLIDINE COMPOUND AND PHARMACEUTICAL USE Eisai Co., Ltd. (JP) 1993-07-28 EP claimed
EP-0476156-A1 SOLID ORAL PREPARATION CONTAINING CATECHOL COMPOUND Eisai Co., Ltd. (JP) 1992-03-25 EP claimed
EP-0381235-A2 Pyrrolidine compound and pharmaceutical use Eisai Co., Ltd. (JP) 1990-08-08 EP claimed
US-5444083-A DOPAMINE AGONIST FOR TREATING OR PREVENTION OF HYPERTENSION OR HEART FAILURE EISAI CO., LTD. (JP) 1995-08-22 US disclosed
EP-0381235-B1 PYRROLIDINE COMPOUND AND PHARMACEUTICAL USE Eisai Co., Ltd. (JP) 1993-07-28 EP disclosed
EP-0381235-A2 Pyrrolidine compound and pharmaceutical use Eisai Co., Ltd. (JP) 1990-08-08 EP disclosed