Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | QDPR | P09417 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7294448 | 1.00 | PARP1 (0.49) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| Bromide SCHEMBL7294464 | 1.00 | PARP1 (0.49) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| SCHEMBL7297389 | 0.99 | PARP1 (0.50) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| SCHEMBL7293999 | 0.99 | PARP1 (0.50) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| SCHEMBL7293987 | 0.99 | PARP1 (0.50) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9427156 | 0.97 | PARP1 (0.49) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9427161 | 0.97 | PARP1 (0.49) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9427149 | 0.97 | PARP1 (0.49) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| Bromide SCHEMBL7443323 | 0.85 | PARP1 (0.45) | PARP1MAPK1KDM4EPMP22ALDH1A1 | |
| Bromide SCHEMBL7443319 | 0.85 | PARP1 (0.45) | PARP1MAPK1KDM4EPMP22ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292521-A | And an organic acid or salt | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | claimed |
| JP-2288855-A | — | — | None | — | — | JP | disclosed |
| EP-0476156-B1 | SOLID ORAL PREPARATION CONTAINING CATECHOL COMPOUND | EISAI CO LTD (JP) | 1996-08-07 | — | — | EP | disclosed |
| US-5444083-A | DOPAMINE AGONIST FOR TREATING OR PREVENTION OF HYPERTENSION OR HEART FAILURE | EISAI CO., LTD. (JP) | 1995-08-22 | — | — | US | disclosed |
| US-5292521-A | And an organic acid or salt | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0381235-B1 | PYRROLIDINE COMPOUND AND PHARMACEUTICAL USE | Eisai Co., Ltd. (JP) | 1993-07-28 | — | — | EP | disclosed |
| EP-0476156-A1 | SOLID ORAL PREPARATION CONTAINING CATECHOL COMPOUND | Eisai Co., Ltd. (JP) | 1992-03-25 | — | — | EP | disclosed |
| JP-H02288855-A | PYRROLIDINE DERIVATIVE | EISAI CO LTD | 1990-11-28 | — | — | JP | disclosed |
| EP-0381235-A2 | Pyrrolidine compound and pharmaceutical use | Eisai Co., Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |