SCHEMBL7294142

SCHEMBL7294142

O=C(CCC1Cc2ccccc2C1)C1C(=S)CN[C@@H]1C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PREP P48147 2/20 0.33
IDO1 P14902 1/20 0.33
KMT2A Q03164 2/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
MEN1 O00255 1/20 0.31
EGFR P00533 1/20 0.31
PRCP P42785 1/20 0.31
TSHR P16473 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
PNMT P11086 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7291631 0.93 PREP (0.35) PREPIDO1KMT2AGAAMAPT
SCHEMBL7293757 0.92 GBA1 (0.38) PREP
SCHEMBL7296404 0.87 GAA (0.36) PREPKMT2AGAAMAPTMEN1
SCHEMBL9791386 0.84 PREP (0.47) PREPTSHR
SCHEMBL9049913 0.83 PREP (0.30) PREP
SCHEMBL7293977 0.83 GAA (0.33) PREPKMT2AGAAMAPTMEN1
SCHEMBL7295266 0.82 PREP (0.39) PREP
SCHEMBL7301552 0.82 PREP (0.39) PREP
SCHEMBL7294861 0.82 PREP (0.39) PREP
SCHEMBL9048296 0.82 KMT2A (0.31) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed