Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065928 | 0.87 | MAOB (0.58) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL339853 | 0.82 | MAOB (0.69) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL8661637 | 0.81 | MEN1 (0.56) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL1072784 | 0.81 | GRM5 (0.62) | MAOBGRM5ALOX5LMNACYP1A2 | |
| SCHEMBL13841458 | 0.81 | GRM5 (0.62) | MAOBGRM5ALOX5LMNACYP1A2 | |
| SCHEMBL7349830 | 0.80 | CYP1A2 (0.58) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL27747848 | 0.79 | MAOB (0.64) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL5845963 | 0.79 | MAOB (0.64) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL4316231 | 0.79 | ALOX5 (0.49) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL28928730 | 0.78 | MRGPRX4 (0.48) | MAOBALOX5LMNACYP1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347766-B1 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | THOMAE GMBH DR K (DE) | 1994-05-25 | — | — | EP | disclosed |
| US-5068325-A | Dopaminergic systems as hypotensives, sedatives, antitussives and/or antiphlogistics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |