SCHEMBL7294262

SCHEMBL7294262

N=C(N)Nc1ccc(C(=O)NCCCCC2C(=O)N(CC(=O)O)CCN2C(=O)CNC(=O)c2ccc(NC(=N)N)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 20/20 0.68
ITGA2B P08514 20/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7287474 0.97 ITGB3 (0.72) ITGB3ITGA2B
SCHEMBL7295717 0.97 ITGB3 (0.69) ITGB3ITGA2B
SCHEMBL6157894 0.97 ITGB3 (0.69) ITGB3ITGA2B
Hydrochloric Acid SCHEMBL7024479 0.97 ITGB3 (0.68) ITGB3ITGA2B
SCHEMBL7298296 0.95 ITGB3 (0.73) ITGB3ITGA2B
SCHEMBL7285653 0.94 ITGB3 (0.71) ITGB3ITGA2B
SCHEMBL6157600 0.91 ITGB3 (0.76) ITGB3ITGA2B
SCHEMBL7293205 0.91 ITGB3 (0.76) ITGB3ITGA2B
SCHEMBL6157611 0.91 ITGB3 (0.81) ITGB3ITGA2B
Hydrochloric Acid SCHEMBL7335225 0.91 ITGB3 (0.75) ITGB3ITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950407-B1 The use of a GP IIb/IIIa antagonist for the manufacture of a medicament suitable for transdermal application by iontophoresis HISAMITSU PHARMACEUTICAL CO (JP) 2002-09-04 EP disclosed
EP-0822931-B1 PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-03-27 EP disclosed
US-6322550-B2 Method for transdermal administration of GP IIb/IIIa antagonist HISAMITSU PHARMACEUTICAL CO., INC. (JP) 2001-11-27 US disclosed
US-20010018568-A1 METHOD FOR TRANSDERMAL ADMINISTRATION OF GP IIB/IIIA ANTAGONIST HISAMITSU PHARMACEUTICAL CO., INC. (JP) 2001-08-30 US disclosed
US-6020334-A Piperazinones, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-02-01 US disclosed
EP-0950407-A1 Method for transdermal administration of GP IIb/IIIa antagonist Takeda Chemical Industries, Ltd. (JP) 1999-10-20 EP disclosed
US-5935963-A (4-GUANIDINOBENZOYLAMINO)ACETYL-3-(3-(4-GUANIDINOBENZOYLAMINO) PROPYL)-2-OXOPIPERAZINE-1-ACETIC ACID OR A SALT; CONTROLLING OR INHIBITING CELL-ADHESION; PLATELET ANTIAGGREGATION WITHOUT LONG HEMORRHAGING; ANTIICHEMIC AGENTS; ANGINA PECTORIS TAKEDA CHEMICAL INDUSTRIES, LTD (JP) 1999-08-10 US disclosed
US-5876756-A SUSTAINED RELEASE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-03-02 US disclosed
US-5792763-A MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS ELI LILLY AND COMPANY (US) 1998-08-11 US disclosed
EP-0835869-A2 New serotonin 5-HT1F agonists ELI LILLY AND COMPANY (US) 1998-04-15 EP disclosed
EP-0822931-A1 PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION Takeda Chemical Industries, Ltd. (JP) 1998-02-11 EP disclosed
EP-0765660-A2 Microcapsules comprising 2-piperazinone-1-acetic acid compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-04-02 EP disclosed
WO-1996033982-A1 PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-10-31 WO disclosed