Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.95 |
| ▸ | GRM6 | O15303 | 2/20 | 0.95 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.95 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.95 |
| ▸ | GSR | P00390 | 2/20 | 0.95 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.95 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.95 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.95 |
| ▸ | GRM5 | P41594 | 1/20 | 0.95 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.95 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.95 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.95 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.95 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.95 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.95 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.95 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.95 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.95 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL31507089 | 1.00 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL28296939 | 1.00 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL7294270 | 1.00 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL7564767 | 0.97 | GRM8 (0.90) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1332297 | 0.97 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1330484 | 0.97 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL410241 | 0.97 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL17127348 | 0.97 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1330824 | 0.97 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL2201 | 0.97 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104685058-B | Microorganisms and methods for making 4-hydroxybutyrate, 1, 4-butanediol, and related compounds | 基因组股份公司 | 2020-07-07 | — | — | CN | claimed |
| US-20190284282-A1 | STABLE PHARMACEUTICAL COMPOSITION | DR. REDDY'S LABORATORIES LIMITED (IN) | 2019-09-19 | — | — | US | claimed |
| EP-3402470-A1 | STABLE PHARMACEUTICAL COMPOSITION | Dr. Reddy's Laboratories Limited (IN) | 2018-11-21 | — | — | EP | claimed |
| CN-108778261-A | Stable pharmaceutical composition | 雷迪博士实验室有限公司 | 2018-11-09 | — | — | CN | claimed |
| WO-2017122121-A1 | STABLE PHARMACEUTICAL COMPOSITION | DR. REDDY'S LABORATORIES LIMITED (IN) | 2017-07-20 | — | — | WO | claimed |
| US-11713705-B2 | Nitrous oxide removal catalysts for exhaust systems | BASF CORPORATION (US) | 2023-08-01 | — | — | US | disclosed |
| US-20220010714-A1 | NITROUS OXIDE REMOVAL CATALYSTS FOR EXHAUST SYSTEMS | BASF MOBILE EMISSIONS CATALYSTS LLC | 2022-01-13 | — | — | US | disclosed |
| EP-3244995-B1 | NITROUS OXIDE REMOVAL CATALYSTS FOR EXHAUST SYSTEMS | BASF CORP (US) | 2021-11-03 | — | — | EP | disclosed |
| US-11149610-B2 | Nitrous oxide removal catalysts for exhaust systems | BASF CORPORATION (US) | 2021-10-19 | — | — | US | disclosed |
| US-20200232366-A1 | NITROUS OXIDE REMOVAL CATALYSTS FOR EXHAUST SYSTEMS | BASF MOBILE EMISSIONS CATALYSTS LLC | 2020-07-23 | — | — | US | disclosed |
| CN-104685058-B | Microorganisms and methods for making 4-hydroxybutyrate, 1, 4-butanediol, and related compounds | 基因组股份公司 | 2020-07-07 | — | — | CN | disclosed |
| US-10634030-B2 | Nitrous oxide removal catalysts for exhaust systems | BASF CORPORATION (US) | 2020-04-28 | — | — | US | disclosed |
| EP-2460539-A1 | NANOSPHERE OR MICROSPHERE DRUG CARRIER, PREPARATION METHOD, COMPOSITION AND USE THEREOF | Xi'an Libang Medical Technology Co., Ltd. (CN) | 2012-06-06 | — | — | EP | disclosed |
| EP-1092766-A1 | MICROORGANISM BELONGING TO THE GENUS CITROBACTER AND PROCESS FOR PRODUCING SHIKIMIC ACID | TORAY INDUSTRIES, INC. (JP) | 2001-04-18 | — | — | EP | disclosed |
| EP-0679084-A4 | — | — | 1995-11-08 | — | — | EP | disclosed |
| EP-0679084-A1 | HYDANTOIN AND SUCCINIMIDE-SUBSTITUTED DERIVATIVES OF SPIROINDANYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS | MERCK & CO. INC. (US) | 1995-11-02 | — | — | EP | disclosed |
| WO-1994014438-A1 | HYDANTOIN AND SUCCINIMIDE-SUBSTITUTED DERIVATIVES OF SPIROINDANYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS | MERCK & CO., INC. (US) | 1994-07-07 | — | — | WO | disclosed |
| US-5137904-A | Useful in the treatment of atherosclerosis and thrombosis | G. D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0486280-A2 | Piperidinylcamphorsulfonyl oxytocin antagonists | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| WO-1992007821-A1 | DIASTEREOISOMERS OF BICYCLO-SUBSTITUTED PHENYLACETONITRILE DERIVATIVES | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |