D-Glutamate

D-Glutamate

SCHEMBL2201

NC(CCC(=O)O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM8 O00222 2/20 1.00
GRM6 O15303 2/20 1.00
GRM7 Q14831 2/20 1.00
GRM4 Q14833 2/20 1.00
GRIN2D O15399 1/20 1.00
GRIN3B O60391 1/20 1.00
GSR P00390 1/20 1.00
CYP1A2 P05177 1/20 1.00
GRIK1 P39086 1/20 1.00
GRM5 P41594 1/20 1.00
GRIA1 P42261 1/20 1.00
GRIA2 P42262 1/20 1.00
GRIA3 P42263 1/20 1.00
SLC1A3 P43003 1/20 1.00
SLC1A2 P43004 1/20 1.00
SLC1A1 P43005 1/20 1.00
GRIA4 P48058 1/20 1.00
GRIN1 Q05586 1/20 1.00
GRIN2A Q12879 1/20 1.00
GRIK2 Q13002 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glutamic Acid SCHEMBL1554237 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL1332297 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL1330484 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
Glutamic Acid SCHEMBL248800 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL931953 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL410241 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
Glutamic Acid SCHEMBL5704264 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL1330824 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL17127348 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL1332144 1.00 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 915801 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6410494-B1 None US claimed
US-9974849-B2 Human Papilloma virus therapeutic vaccine BIOVENTURES, LLC (US) 2018-05-22 US claimed
US-9975915-B1 Crystalline forms of nicotinoyl ribosides, modified derivatives thereof, and phosphorylated analogs thereof, and methods of preparation thereof THE QUEEN'S UNIVERSITY OF BELFAST (GB) 2018-05-22 US claimed
US-9976074-B2 Self-suspending proppant particulates using canola protein-based hydrogel HALLIBURTON ENERGY SERVICES, INC. (US) 2018-05-22 US claimed
US-9976111-B2 TiN hard mask and etch residual removal VERSUM MATERIALS US, LLC (US) 2018-05-22 US claimed
WO-2018089394-A1 ORAL CARE COMPOSITIONS COLGATE-PALMOLIVE COMPANY (US) 2018-05-17 WO claimed
US-20180134677-A1 NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2018-05-17 US claimed
US-20180133133-A1 STRUCTURED CRYSTALLINE SURFACTANT COMPOSITIONS EVONIK OPERATIONS GMBH (DE) 2018-05-17 US claimed
US-20180134743-A1 EFFICIENT AND SCALABLE SYNTHESES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS THEREOF, ADENYLYL DINUCLEOTIDE CONJUGATES THEREOF, AND NOVEL CRYSTALLINE FORMS THEREOF THE QUEEN'S UNIVERSITY OF BELFAST (GB) 2018-05-17 US claimed
US-20180134742-A1 CRYSTALLINE FORMS OF NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, AND PHOSPHORYLATED ANALOGS THEREOF, AND METHODS OF PREPARATION THEREOF THE QUEEN'S UNIVERSITY OF BELFAST (GB) 2018-05-17 US claimed
US-3968218-A Cosmetic composition containing a hydroxylated amino thioether for application to the hair and skin L'OREAL (FR) 1976-07-06 US claimed
US-3966749-A Novel synthesis of optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols, the pharmaceutically acceptable acid addition salts thereof and intermediate useful in the preparation thereof INTERX RESEARCH CORPORATION (US) 1976-06-29 US claimed
US-3963579-A Microbiological process for the production of pepstatins SANRAKU-OCEAN CO., LTD. (JA) 1976-06-15 US claimed
US-3960476-A OXIDATION BASE GHILARDI GIULIANA 1976-06-01 US claimed
US-3958581-A Cosmetic composition containing a cationic polymer and divalent metal salt for strengthening the hair L'OREAL (FR) 1976-05-25 US claimed
US-3956481-A Hydrosoluble extracts of mycobacteria, their preparation and use AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) 1976-05-11 US claimed
US-3956040-A Explosive slurry composition containing sodium montmorillonite GELAN KABUSHIKI KAISHA (JA) 1976-05-11 US claimed
US-3953416-A Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same FOLKERS KARL 1976-04-27 US claimed
US-3950555-A Method of tenderizing and improving the flavor of food STROMBERG BENGT 1976-04-13 US claimed
US-3933783-A Formation of peptide bonds in the presence of isonitriles AJINOMOTO CO., INC. (JA) 1976-01-20 US claimed