Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6085892 | 0.91 | ELANE (0.60) | ELANENPC1RAB9AP2RX3 | |
| SCHEMBL6085435 | 0.86 | ELANE (0.67) | ELANENPC1RAB9A | |
| SCHEMBL6558401 | 0.85 | ELANE (0.56) | ELANENPC1RAB9AP2RX3 | |
| SCHEMBL6557626 | 0.85 | ELANE (0.54) | ELANENPC1RAB9AP2RX3 | |
| SCHEMBL6558159 | 0.84 | ELANE (0.63) | ELANE | |
| SCHEMBL6556223 | 0.84 | ELANE (0.62) | ELANENPC1RAB9AP2RX3 | |
| SCHEMBL6558347 | 0.84 | ELANE (0.58) | ELANENPC1RAB9AP2RX3 | |
| SCHEMBL7959223 | 0.83 | ELANE (0.47) | ELANEP2RX3 | |
| SCHEMBL6558341 | 0.83 | ELANE (0.62) | ELANENPC1RAB9AP2RX3 | |
| SCHEMBL6558418 | 0.82 | ELANE (0.64) | ELANENPC1RAB9AP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| US-5736535-A | 1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 1998-04-07 | — | — | US | disclosed |
| EP-0636143-B1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |
| US-5441960-A | 1-pyrimidinylacetamide human leukocyte elastate inhibitors | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0636141-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS. | ZENECA LTD (GB) | 1995-02-01 | — | — | EP | disclosed |
| EP-0636143-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS. | ZENECA LTD (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021214-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| WO-1993021210-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |