Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30639518 | 0.92 | KMT2A (0.65) | MTNR1AMTNR1BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30639528 | 0.91 | KMT2A (0.64) | MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL21449764 | 0.90 | MEN1 (0.72) | HDAC1HDAC6MTNR1AMTNR1BMEN1 | |
| SCHEMBL27419965 | 0.90 | EPHX2 (0.75) | MTNR1AMTNR1BEPHX2 | |
| SCHEMBL17283413 | 0.89 | EPHX2 (0.77) | HDAC1HDAC6MTNR1AMTNR1BEPHX2 | |
| SCHEMBL3199590 | 0.87 | MTNR1A (0.62) | HDAC1HDAC6MTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL1665670 | 0.86 | MTNR1A (0.61) | MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL23026415 | 0.85 | HDAC1 (0.61) | HDAC1HDAC6MTNR1AMTNR1BEPHX2 | |
| SCHEMBL29722609 | 0.85 | MTNR1A (0.67) | MTNR1AMTNR1BEPHX2 | |
| SCHEMBL24528927 | 0.85 | MTNR1A (0.67) | MTNR1AMTNR1BEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223598-B1 | CATECHOLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | FISONS plc (GB) | 1991-06-12 | — | — | EP | disclosed |
| US-4939147-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC. (GB) | 1990-07-03 | — | — | US | disclosed |
| US-4922022-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| US-4883804-A | Aromatic compounds | FISONS PLC (GB) | 1989-11-28 | — | — | US | disclosed |
| EP-0223598-A2 | Catecholamine derivatives, processes for their preparation and pharmaceutical compositions thereof | FISONS plc (GB) | 1987-05-27 | — | — | EP | disclosed |