Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.46 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | TACR2 | P21452 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304240 | 0.98 | ALDH1A1 (0.44) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7298307 | 0.95 | ALDH1A1 (0.45) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7295179 | 0.93 | MEN1 (0.48) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL10841283 | 0.93 | ALDH1A1 (0.46) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7327631 | 0.93 | ALDH1A1 (0.43) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7294115 | 0.93 | ALDH1A1 (0.43) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7333223 | 0.93 | MEN1 (0.40) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL16892516 | 0.91 | ALDH1A1 (0.49) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL16892524 | 0.91 | ALDH1A1 (0.45) | CYP3A4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL16058457 | 0.91 | ALDH1A1 (0.45) | CYP3A4ALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |