Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | REN | P00797 | 12/20 | 0.57 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290892 | 0.96 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7290790 | 0.92 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10444305 | 0.89 | ERAP2 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7292589 | 0.86 | CAPN1 (0.58) | RENCTSSCTSK | |
| SCHEMBL10444298 | 0.85 | ACE (0.51) | — | |
| SCHEMBL7292800 | 0.85 | REN (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10444617 | 0.84 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7298803 | 0.84 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10339094 | 0.83 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10444334 | 0.83 | REN (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356223-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1990-02-28 | — | — | EP | disclosed |
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |