Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877943 | 0.97 | PDE3B (0.49) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL7295007 | 0.94 | PDE3B (0.51) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL7294767 | 0.92 | PDE3B (0.60) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL9178917 | 0.91 | PDE3B (0.51) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL10424706 | 0.86 | PDE3B (0.46) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL7295019 | 0.85 | PDE3B (0.60) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL10424705 | 0.85 | PDE3B (0.44) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL9877075 | 0.84 | PDE3B (0.49) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL9180425 | 0.84 | PDE3B (0.52) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL9877370 | 0.83 | GPR119 (0.45) | PDE3BPDE3AGPR119ABCB11MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4957920-A | INOTROPIC | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-18 | — | — | US | claimed |
| EP-0310737-A1 | Benzimidazoles, process for their preparation and medicines containing them | HEUMANN PHARMA GMBH & CO (DE) | 1989-04-12 | — | — | EP | claimed |
| JP-1096180-A | — | — | None | — | — | JP | disclosed |
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| US-5039675-A | Cardiovascular disorders | HEUMANN PHARMA GMBH & CO. (DE) | 1991-08-13 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |
| US-4957920-A | INOTROPIC | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-18 | — | — | US | disclosed |
| JP-H0196180-A | BENZIMIDAZOLE COMPOUND, ITS PRODUCTION AND COMPOSITION FOR TREATING CARDIAL FUNCTION INSUFFICIENCY | HEUMANN PHARMA GMBH & CO | 1989-04-14 | — | — | JP | disclosed |
| EP-0310737-A1 | Benzimidazoles, process for their preparation and medicines containing them | HEUMANN PHARMA GMBH & CO (DE) | 1989-04-12 | — | — | EP | disclosed |