Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | TP53 | P04637 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9696412 | 0.89 | NR1H4 (0.77) | NR1H4SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL95373 | 0.84 | NPC1 (0.59) | NR1H4SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL14347581 | 0.84 | KMT2A (0.74) | SMN1; SMN2TP53MAPTNPC1RAB9A | |
| SCHEMBL7301385 | 0.84 | NPC1 (0.69) | NR1H4SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL7301440 | 0.82 | SMN1; SMN2 (0.78) | NR1H4SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL7295519 | 0.80 | NPC1 (0.66) | NR1H4SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL21588673 | 0.80 | HDAC6 (0.67) | NR1H4SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL25721410 | 0.80 | HDAC6 (0.67) | NR1H4SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL7303163 | 0.78 | HDAC3 (0.86) | NR1H4SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL9447193 | 0.78 | CYP1A2 (0.56) | MAPTLMNAALDH1A1GRM4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358118-B1 | Phenylamides - process for their preparation as well as a drug containing those compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-16 | — | — | EP | disclosed |
| US-5135949-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0358118-A1 | Phenylamides - process for their preparation as well as a drug containing those compounds | Roche Diagnostics GmbH (DE) | 1990-03-14 | — | — | EP | disclosed |