Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.55 |
| ▸ | EDNRB | P24530 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627598 | 0.87 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL31559141 | 0.87 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL31559142 | 0.87 | EDNRA (0.70) | EDNRAEDNRB | |
| Potassium SCHEMBL31559138 | 0.86 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL629196 | 0.86 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL7297111 | 0.85 | EDNRA (0.57) | EDNRAEDNRB | |
| SCHEMBL7306773 | 0.85 | EDNRA (0.57) | EDNRAEDNRB | |
| Dimethyl Sulfoxide SCHEMBL627619 | 0.84 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL7294305 | 0.82 | EDNRB (0.71) | EDNRAEDNRB | |
| SCHEMBL8327749 | 0.81 | EDNRA (0.55) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |