Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10965755 | 0.87 | KDM4E (0.49) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL14925980 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL3294572 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL1704641 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL18948659 | 0.83 | KDM4E (0.51) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL1953381 | 0.82 | KDM4E (0.50) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL1953383 | 0.82 | KDM4E (0.50) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL12125004 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL7118053 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL29020320 | 0.81 | NR1I2 (0.53) | ALDH1A1KDM4ETSHRMAPK1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| US-5364844-A | Hypotensive agents | SANKYO COMPANY, LIMITED (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0326364-B1 | Renin inhibitory oligopeptides, their preparation and use | SANKYO CO (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0326364-A2 | Renin inhibitory oligopeptides, their preparation and use | Sankyo Company Limited (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |