Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.81 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.63 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.63 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.63 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360959 | 1.00 | SIGMAR1 (0.81) | SIGMAR1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL26985759 | 0.98 | SIGMAR1 (0.77) | SIGMAR1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL4819795 | 0.94 | SIGMAR1 (0.77) | SIGMAR1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL7298415 | 0.94 | SIGMAR1 (0.76) | SIGMAR1 | |
| SCHEMBL4016136 | 0.92 | SIGMAR1 (0.75) | SIGMAR1 | |
| SCHEMBL1774154 | 0.92 | SIGMAR1 (0.81) | SIGMAR1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL13073491 | 0.90 | SIGMAR1 (0.74) | SIGMAR1 | |
| SCHEMBL27456705 | 0.90 | SIGMAR1 (0.77) | SIGMAR1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL9655857 | 0.90 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9819830 | 0.90 | SIGMAR1 (1.00) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |