Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556302 | 0.91 | ELANE (0.62) | ELANEHDAC3HDAC1HDAC2 | |
| SCHEMBL6086170 | 0.87 | ELANE (0.62) | ELANEP2RX3NPC1RAB9A | |
| SCHEMBL6556446 | 0.86 | ELANE (0.69) | ELANEHDAC3HDAC1HDAC2 | |
| SCHEMBL6557614 | 0.84 | ELANE (0.62) | ELANEHDAC3HDAC1HDAC2P2RX3 | |
| SCHEMBL7274678 | 0.84 | HDAC3 (0.49) | ELANEHDAC3HDAC1HDAC2NPC1 | |
| SCHEMBL7301356 | 0.82 | ELANE (0.64) | ELANEP2RX3 | |
| SCHEMBL8401271 | 0.81 | ELANE (0.58) | ELANEHDAC3HDAC1HDAC2P2RX3 | |
| SCHEMBL7863330 | 0.80 | ELANE (0.70) | ELANE | |
| SCHEMBL7208083 | 0.79 | ELANE (0.68) | ELANE | |
| SCHEMBL9584587 | 0.78 | ELANE (0.79) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |