Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.64 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086170 | 0.93 | ELANE (0.62) | ELANEP2RX3 | |
| SCHEMBL6558295 | 0.91 | ELANE (0.62) | ELANEP4HTM | |
| SCHEMBL7289416 | 0.86 | ELANE (0.64) | ELANEP4HTM | |
| SCHEMBL6558251 | 0.86 | ELANE (0.69) | ELANEP4HTM | |
| SCHEMBL6558341 | 0.84 | ELANE (0.62) | ELANEP4HTMP2RX3 | |
| SCHEMBL6557678 | 0.83 | ELANE (0.60) | ELANEP2RX3 | |
| SCHEMBL6556313 | 0.82 | ELANE (0.55) | ELANE | |
| SCHEMBL7296453 | 0.82 | ELANE (0.64) | ELANEP2RX3 | |
| SCHEMBL8405263 | 0.81 | ELANE (0.58) | ELANEP4HTM | |
| SCHEMBL6556275 | 0.80 | ELANE (0.57) | ELANEP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |