Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.69 |
| ▸ | DRD1 | P21728 | 3/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | DRD3 | P35462 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.67 |
| ▸ | GBA1 | P04062 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10750998 | 0.96 | CYP2D6 (0.67) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL9866638 | 0.92 | CYP2D6 (0.72) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10652605 | 0.88 | GBA1 (0.66) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10754717 | 0.86 | GBA1 (0.53) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL7418708 | 0.86 | GBA1 (0.67) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10673689 | 0.86 | GBA1 (0.53) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10753463 | 0.86 | GBA1 (0.56) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10654553 | 0.85 | CHRM2 (0.51) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL14980581 | 0.85 | CYP2D6 (0.85) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10652606 | 0.84 | CHRM2 (0.64) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262448-B1 | IMIDAZOLYLGUANIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1991-12-18 | — | — | EP | disclosed |
| US-4912119-A | Cardiovascular disorders | HEUMANN PHARMA GMBH & CO. (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0113572-B1 | PYRIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-02-03 | — | — | EP | disclosed |
| EP-0112704-B1 | PYRIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-10-07 | — | — | EP | disclosed |
| US-4659725-A | 3-(2-pyridylaminoalkylamino)cyclobutenediones and pyridones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| US-4607106-A | 3-(2-pyridylaminoalkylamino)thiazoles useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-08-19 | — | — | US | disclosed |
| US-4547506-A | 2-Pyridylaminoakylamino-4-pyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-15 | — | — | US | disclosed |
| US-4532246-A | 2-(2-Pyridylaminoalkylamino)-4-pyrimidones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-07-30 | — | — | US | disclosed |
| EP-0113572-A2 | Pyridine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-18 | — | — | EP | disclosed |
| EP-0112704-A2 | Pyridine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-04 | — | — | EP | disclosed |