Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.72 |
| ▸ | DRD1 | P21728 | 3/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | DRD3 | P35462 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296557 | 0.92 | CYP2D6 (0.69) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10750998 | 0.90 | CYP2D6 (0.67) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL7095181 | 0.88 | CHRM2 (0.69) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL14813465 | 0.85 | CYP2D6 (0.72) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Chloropyramine SCHEMBL30021 | 0.84 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Chloropyramine SCHEMBL30566745 | 0.84 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Chloropyramine SCHEMBL538104 | 0.83 | KDM4E (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Chloropyramine SCHEMBL34463428 | 0.83 | KDM4E (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL7289564 | 0.82 | CYP2D6 (0.68) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL9574744 | 0.82 | LMNA (0.76) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |