Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.63 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20212813 | 0.77 | OPRM1 (1.00) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL21179618 | 0.77 | OPRM1 (1.00) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL20212814 | 0.77 | OPRM1 (1.00) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7303197 | 0.77 | OPRM1 (0.41) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL28623424 | 0.73 | OPRM1 (0.53) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL663 | 0.72 | POLB (0.47) | OPRM1OPRD1OPRK1OPRL1KDM1A | |
| SCHEMBL12490206 | 0.69 | OPRM1 (0.67) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7334925 | 0.69 | KDM1A (0.47) | KDM1A | |
| SCHEMBL28623404 | 0.69 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL28613180 | 0.69 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385722-B1 | Tricyclic lactam derivatives and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| EP-0385722-A2 | Tricyclic lactam derivatives and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |