Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.58 |
| ▸ | CTSS | P25774 | 3/20 | 0.58 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | CTSH | P09668 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099322 | 0.98 | CTSK (0.55) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL11096635 | 0.88 | CTSK (0.46) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL3709454 | 0.85 | CTSK (0.46) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL1424546 | 0.84 | CTSK (0.65) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL21427217 | 0.84 | CTSK (0.65) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL23118362 | 0.84 | CTSK (0.65) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL5063217 | 0.84 | CTSK (0.65) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL21119399 | 0.84 | CTSK (0.65) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL1738774 | 0.84 | CTSK (0.53) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL9099948 | 0.84 | CTSK (0.53) | CTSKCTSSAAK1HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |