Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18795778 | 0.92 | HDAC6 (0.53) | HDAC6HDAC1HDAC8HDAC4NPC1 | |
| SCHEMBL21175923 | 0.89 | HDAC4 (0.54) | HDAC6HDAC1HDAC8HDAC4NR1H4 | |
| SCHEMBL18796097 | 0.89 | HDAC4 (0.63) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL18795910 | 0.89 | HDAC6 (0.51) | HDAC6HDAC1HDAC8HDAC4NPC1 | |
| SCHEMBL18824381 | 0.86 | HDAC4 (0.66) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL25313803 | 0.84 | HDAC4 (0.56) | HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL7292274 | 0.83 | HDAC4 (0.56) | HDAC6HDAC1HDAC8HDAC4TP53 | |
| SCHEMBL28860581 | 0.83 | HDAC6 (0.53) | HDAC6HDAC1HDAC8HDAC4SMN1; SMN2 | |
| SCHEMBL19961255 | 0.83 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL28641277 | 0.82 | HDAC1 (0.50) | HDAC6HDAC1HDAC8HDAC4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0504574-B1 | 1,2,4-Oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity and method for preparing same | WAKAMOTO PHARMA CO LTD (JP) | 1996-02-28 | — | — | EP | claimed |
| EP-0504574-B1 | 1,2,4-Oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity and method for preparing same | WAKAMOTO PHARMA CO LTD (JP) | 1996-02-28 | — | — | EP | disclosed |