Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297867 | 1.00 | CA2 (0.42) | CA2CA1TSHRATMACHE | |
| SCHEMBL28944403 | 0.90 | CA2 (0.39) | CA2CA1TSHRATMACHE | |
| SCHEMBL6924069 | 0.87 | ZDHHC7 (0.42) | CA2CA1ZDHHC7FAAHLMNA | |
| SCHEMBL3177902 | 0.86 | TSHR (0.42) | CA2CA1TSHRATMCYP3A4 | |
| SCHEMBL28728349 | 0.85 | ZDHHC7 (0.40) | CA1ZDHHC7FAAHCPB2 | |
| SCHEMBL12120678 | 0.84 | ZDHHC7 (0.44) | ZDHHC7FAAHLMNA | |
| SCHEMBL12437842 | 0.84 | ZDHHC7 (0.44) | ZDHHC7FAAHLMNA | |
| SCHEMBL7909171 | 0.84 | TSHR (0.45) | CA2CA1TSHRATMCYP3A4 | |
| SCHEMBL12120663 | 0.83 | ZDHHC7 (0.39) | ZDHHC7FAAHLMNA | |
| SCHEMBL7636810 | 0.81 | CA2 (0.38) | CA2CA1TSHRATMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915088-B1 | D-Proline derivatives | HOFFMANN LA ROCHE (CH) | 2002-09-18 | — | — | EP | disclosed |
| EP-0915088-A1 | D-Proline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-12 | — | — | EP | disclosed |