Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17478870 | 0.82 | CYP19A1 (0.35) | CYP19A1RARBRARGTSHRNPSR1 | |
| SCHEMBL7297283 | 0.76 | ALDH1A1 (0.51) | RARBRARGKMT2AALDH1A1TSHR | |
| SCHEMBL15330888 | 0.75 | RARB (0.33) | RARBRARGKMT2ATSHRNPSR1 | |
| SCHEMBL6249654 | 0.74 | KMT2A (0.33) | RARBRARGKMT2ATSHRNPSR1 | |
| SCHEMBL12157511 | 0.74 | GRIA1 (0.41) | CASP7TDP2CA9 | |
| SCHEMBL10332350 | 0.73 | MAPK14 (0.42) | KMT2AKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL7268304 | 0.73 | BACE1 (0.33) | CYP19A1RARBRARGBACE1 | |
| SCHEMBL5764522 | 0.72 | PDE7A (0.46) | RARBRARGKDM4EALDH1A1HPGD | |
| SCHEMBL6222533 | 0.72 | KMT2A (0.31) | RARBRARGKMT2A | |
| SCHEMBL5768388 | 0.72 | RARB (0.38) | RARBRARGKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898872-A | Imidazo[4,5-b]pyridyl quinolone cardiac stimulants | PFIZER INC. (US) | 1990-02-06 | — | — | US | disclosed |
| EP-0290153-A1 | Heterobicyclic quinolone derivatives | Pfizer Limited (GB) | 1988-11-09 | — | — | EP | disclosed |