Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Idaverine SCHEMBL180957 | 0.74 | TSHR (0.46) | NPC1RAB9ATSHRKMT2AALDH1A1 | |
| Idaverine SCHEMBL7286939 | 0.74 | TSHR (0.46) | NPC1RAB9ATSHRKMT2AALDH1A1 | |
| Idaverine SCHEMBL10340527 | 0.73 | CYP3A4 (0.47) | NPC1RAB9ATSHRKMT2AALDH1A1 | |
| SCHEMBL10483364 | 0.67 | CYP3A4 (0.36) | NPC1RAB9ATSHRKMT2AALDH1A1 | |
| SCHEMBL10483360 | 0.67 | CYP3A4 (0.36) | NPC1RAB9ATSHRKMT2AALDH1A1 | |
| SCHEMBL10868814 | 0.67 | TSHR (0.45) | NPC1RAB9ATSHRKMT2AALDH1A1 | |
| SCHEMBL10483403 | 0.67 | CYP3A4 (0.46) | NPC1RAB9ATSHRKMT2AALDH1A1 | |
| SCHEMBL10483375 | 0.66 | DRD2 (0.52) | EPHX2ACHE | |
| SCHEMBL10483516 | 0.66 | POLB (0.43) | TSHRALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL10483388 | 0.66 | EPHX2 (0.41) | NPC1RAB9ATSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402733-A2 | Agent for the treatment of central nervous system illnesses and for the enhancement of cerebral blood flow | Dr. Karl Thomae GmbH (DE) | 1990-12-19 | — | — | EP | claimed |
| EP-0324348-A2 | Derivatives of piperidincarboxamide for the treatment of Bradycardia and Bradyarrhythmia | Dr. Karl Thomae GmbH (DE) | 1989-07-19 | — | — | EP | claimed |