Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300410 | 0.91 | SIGMAR1 (0.83) | SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL7290395 | 0.91 | SIGMAR1 (0.83) | SIGMAR1ALDH1A1KMT2AGRM2 | |
| SCHEMBL7290629 | 0.87 | SIGMAR1 (0.65) | SIGMAR1ALDH1A1GRM2MAPT | |
| SCHEMBL7291491 | 0.87 | SIGMAR1 (0.65) | SIGMAR1ALDH1A1GRM2MAPT | |
| SCHEMBL7299514 | 0.86 | SIGMAR1 (0.64) | SIGMAR1GRM2 | |
| SCHEMBL7290882 | 0.84 | SIGMAR1 (0.67) | SIGMAR1LMNA | |
| SCHEMBL7291745 | 0.84 | SIGMAR1 (0.70) | SIGMAR1GRM2 | |
| SCHEMBL7300307 | 0.82 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL7298734 | 0.81 | SIGMAR1 (0.57) | SIGMAR1ALDH1A1GRM2LMNA | |
| SCHEMBL7293138 | 0.80 | SIGMAR1 (0.61) | SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459256-B1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GMBH (DE) | 1995-07-12 | — | — | EP | disclosed |
| US-5232931-A | OXAZOLIDINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0459256-A1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GmbH (DE) | 1991-12-04 | — | — | EP | disclosed |